Figure 2
From: Derivation of HLA types from shotgun sequence datasets
HLAminer performance. HLA allele group and protein coding allele predictions derived from targeted read assembly (black symbols) or direct read alignment (grey symbols) of simulated 100-nucleotide RNA-Seq, WGS and exon capture (ExCap) datasets were compared to original, spiked-in, HLA sequences and performance metrics evaluated (ambiguity, sensitivity and specificity represented by circle, triangle and square symbols, respectively). HLAminer predictions were also obtained from targeted assembly of colorectal cancer (CRC; blue symbols), lymphoma (DLBCL; red, orange and yellow symbols), 1000 Genomes (1KG; green symbols) and ovarian cancer (OV; violet and magenta symbols) patient tumor (T) and/or matched normal (N) shotgun datasets and compared to PCR-based HLA types to calculate performance metrics.