Fig. 5

Mendelian randomisation (MR) analysis on DNAm and depression using data from the Genetics of DNA Methylation Consortium (GoDMC). a Discovery MR testing causal effect of DNAm to depression using GoDMC data. b Replication MR testing effect of DNAm using GS data to depression. c MR of reversed directionality testing the causal effect from depression to DNAm. X-axes represent p-values for MR analyses. Y-axes represent the individual tests conducted