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Fig. 7 | Genome Medicine

Fig. 7

From: Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

Fig. 7

The identification of a multi-lateral network associated with continued tumour cell proliferation in within the drug-treated tumour microenvironment interface. a Proposed hypothesis facilitating continued proliferation of tumour cells at the interface, a consequence of interactions between proliferative tumour GNPs and host cell types such as microglia and astrocytes. b DAPI and H&E image overview of a drug-treated tumour, Palbociclib G. c Representative target RNA molecule expression at a single-cell level using RNAscope for gene markers of cell types and associated ligands and receptors of proposed hypothesis: microglia (Cd68, Aif1, Igf1, Il4r), astrocytes (S100b, Gfap, Il4) and proliferating tumour cells (MKI67) within the tumour microenvironment interface and d tumour bulk. GNPs granule neuron progenitors, TMAs tumour-associated microglia. Scale bar: 5 µm

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Genome Medicine

ISSN: 1756-994X

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