Fig. 6
From: Prostate cancers with distinct transcriptional programs in Black and White men
A network of top 10 TFs in Black men and its clinical association. A A network model shows the transcriptional regulatory network of the top 10 TFs in Black men. Node size represents the proportion of number of targets in DEGs. Node color represents the activity difference of 10 TFs between Black and White men in the DVAHCS cohort. Edge color and width represent the proportion of co-regulated genes in DEGs. B Box plot shows the distribution of top 10 Black TF activity by race and Gleason score in the DVAHCS cohort. C Box plot shows the distribution of top 10 Black TF activity by race and Gleason score in the MIRS (left) and Emory (right) cohorts. D Box plot shows the distribution of top 10 Black TF activity by race and Decipher risk groups in the MIRS cohort