Fig. 2

Higher VUS prevalence found in individuals of non-European-like genetic ancestry across medical specialties. Box plots corresponding to VUS allele prevalence (x-axis) in each gene (dot) for individuals of non-European-like (blue) versus European-like (orange) genetic ancestry for the corresponding medical specialty (y-axis) as best visualized in All of Us v7 for all coding variants. Genes with zero alleles for allele prevalence for either individuals of European-like or non-European-like genetic ancestry are omitted from the above visualization to maintain a reasonable scale for data visualization. However, genes with zero alleles for only one category of either individuals of European-like or non-European-like genetic ancestry are included in the Bonferroni-corrected, signed rank, matched pairs Wilcoxon statistical test. The Bonferroni-corrected p values associated with these comparisons are annotated as follows with “ns” indicating not significant, * for 1.19e − 04 < p ≤ 2.38e − 04, ** for 5.95e − 05 < p ≤ 1.19e − 04, *** for 5.95e − 06 < p ≤ 5.95e − 05, and **** for p ≤ 5.95e − 06. Across all medical specialties and categories shown, VUS are observed to be statistically significantly increased in individuals of non-European-like genetic ancestry compared to individuals of European-like genetic ancestry