Table 1 Characteristics of the CVE cohort
From: Epigenetic age and long-term cancer risk following a stroke
Global (N = 648) | No cancer (N = 565) | Cancer (N = 83) | p value | |
|---|---|---|---|---|
Chronological age | 73.0 (62.0;80.0) | 74.0 (62.0;80.0) | 72.0 (62.5;77.5) | 0.301 |
Male sex | 385 (59.4%) | 326 (57.7%) | 59 (71.1%) | 0.028 |
Hypertension | 468 (72.2%) | 404 (71.5%) | 64 (77.1%) | 0.351 |
Diabetes mellitus | 241 (37.2%) | 209 (37.0%) | 32 (38.6%) | 0.878 |
Dyslipidemia | 439 (67.7%) | 376 (66.5%) | 63 (75.9%) | 0.115 |
Atrial fibrillation | 165 (25.5%) | 147 (26.0%) | 18 (21.7%) | 0.477 |
Ischemic heart disease | 82 (12.7%) | 69 (12.2%) | 13 (15.7%) | 0.480 |
Peripheral arterial disease | 62 (9.57%) | 52 (9.20%) | 10 (12.0%) | 0.533 |
Carotid atherosclerosis | 173 (30.6%) | 144 (29.2%) | 29 (39.7%) | 0.092 |
Previous stroke | 44 (6.79%) | 42 (7.43%) | 2 (2.41%) | 0.143 |
Antiplatelet drug treatment | 423 (65.3%) | 363 (64.2%) | 60 (72.3%) | 0.189 |
Smoking habit | 225 (33.0%) | 182 (32.7%) | 29 (35.4%) | 0.720 |
Excessive alcohol consumption | 159 (30.1%) | 161 (28.5%) | 34 (41.0%) | 0.031 |
Body mass index | 26.9 (24.3;30.4) | 27.0 (24.4;30.5) | 26.5 (24.2;29.4) | 0.506 |
Etiological CVE subtypes | 0.684 | |||
Atherothrombotic | 166 (25.6%) | 140 (24.8%) | 26 (31.3%) | |
Cardioembolic | 161 (24.8%) | 144 (25.5%) | 17 (20.5%) | |
Lacunar | 199 (30.7%) | 174 (30.8%) | 25 (30.1%) | |
Undetermined | 41 (6.33%) | 35 (6.19%) | 6 (7.23%) | |
Hemorrhagic | 81 (12.5%) | 72 (12.7%) | 9 (10.8%) | |
Transient ischemic attack | 80 (12.3%) | 72 (12.7%) | 8 (9.64%) | 0.532 |
Baseline NIHSS | 4.00 (2.00;7.00) | 4.00 (2.00;8.00) | 4.00 (3.00;6.00) | 0.892 |
NIHSS at 24 h | 4.00 (2.00;7.00) | 4.00 (2.00;7.00) | 3.00 (2.00;6.00) | 0.275 |
Poor outcome | 220 (34.1%) | 201 (35.8%) | 19 (22.9%) | 0.029 |
Batch | 1.000 | |||
450 K | 410 (63.3%) | 357 (63.2%) | 53 (63.9%) | |
EPIC | 238 (36.7%) | 208 (36.8%) | 30 (36.1%) |