Fig. 4

MixMHCpred3.0 leads to high-quality MHC-I ligand predictions. A–C LOA cross-validation AUC and PRAUC values for the predictions of peptides presented by MHC-I molecules for alleles that are not part of the training set of A NetMHCpan, B MHCflurry or C BigMHC. D AUC and PRAUC values for the predictions of peptides presented by MHC-I coming from 40 samples in 3 different studies not included in the training set of any of the four predictors. E Benchmarking of PRIME2.1 on CD8 + T-cell epitope samples based on 10-fold cross-validation. P-values from a paired two-sided Wilcoxon signed rank test are indicated