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Table 3 Comparison of birth EWAS (i.e., prospective analysis) versus childhood EWAS (i.e., cross-sectional analysis): Overview of study findings

From: Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Outcome

Change from birth to childhood EWAS

Potential contributing factors

Sensitivity analyses

Correlation analyses

Effect size

Statistical significance

EWAS sample size

Between-study heterogeneity

Do results hold when making N equal across time points?

Do results hold within single longitudinal cohort (ALSPAC)

Correlations between time points (i.e., stability)

Correlations with other phenotypes

ADHD

 = 

(rs = 0.31)

(rs = − 0.18–0.35)

GPF

 = 

 = 

 = 

 ≠ (rs = 0.08)

(rs = − 0.07–0.35)

Sleep

 = 

 ≠ (rs = 0.06)

 ≠ (rs = − 0.04–0.06)

BMI

 ≠ (rs = 0.05)

(rs = − 0.18–0.06)

Asthma

 = 

 ≠ (rs = − 0.04)

(rs = − 0.16–0.21)