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Fig. 6 | Genome Medicine

Fig. 6

From: DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation

Fig. 6

Consistent transcription factor motif enrichment at mouse ADM and human PanIN DMRs. A Motif enrichment analysis results at AK ADM vs acinar hypo DMRs at day 2 (top) and day 4 (bottom). B Motif enrichment analysis results at AK ADM vs acinar hyper DMRs at day 2 (top) and day 4 (bottom). A, B: normal acinar, n = 4 mice; day 2 ADM, n = 2 mice; day 4 ADM, n = 2 mice. Motif enrichment analysis results at human PanIN vs acinar hypo DMRs (C) and hyper DMRs (D). n = 8 acinar donors, n = 14 PanIN lesions from 8 donors. p-adj: Adjusted p-values via Benjamini–Hochberg correction

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Genome Medicine

ISSN: 1756-994X

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