Fig. 5
The PGSheight improves model discrimination between children with ISS-NF and pathologic growth disorders. A Scatter plot showing the relationship between the PGSheight and receiving a diagnosis of ISS-NF in the cohort of children with either ISS-NF or pathologic growth disorders. Logistic regression, adjusting for 10 PCs, was used to generate predicted probabilities of ISS. The gold line denotes the baseline probability of being classified as having ISS-NF. B Forest plot comparing discrimination (AUC) between ISS-NF and pathologic growth disorders when using a model with only age, sex, and 10 PCs (black), with addition of the MPH (blue) and with addition of the PGSheight (purple). Additional sensitivity analyses examined subgroups of children: (1) meeting the clinical definition of short stature at the initial visit (height SDS ≤  − 2), (2) with a diagnosis of a primary growth disorder, and (3) with a diagnosis of a secondary growth disorder