Fig. 2

A Heritability enrichment estimates for OCRs in asthma-relevant cell types. Lymphoid: lung B cells, lung T cells, lung NK cells, blood B cells, blood T cells, blood NK cells; Myeloid: lung macrophage, blood myeloid dendritic cells, blood plasmacytoid dendritic cells, blood monocytes; Epithelial: alveolar type 1 cells, alveolar type 2 cells, pulmonary neuroendocrine cells, lung basal cells, lung ciliated cells, lung club cells, bronchial epithelial cells; Mesenchymal: lung matrix fibroblasts, lung myofibroblasts, lung pericytes, airway smooth muscle cells; Endothelial: lung arterial cells, lung capillary cells, lung lymphatic cells. Confidence intervals are ± 2 standard errors. B PIPs for SNPs in adult-onset asthma (left panel) and childhood-onset asthma (right panel) fine-mapping, with SNPs weighted by functional annotations (y-axis) or by uniform weights (x-axis). C Distribution of the number of SNPs in the adult-onset asthma and childhood-onset asthma credible sets. D Distribution of the number of shared and specific credible sets