Fig. 3

A Cellular contexts of adult-onset asthma credible sets based on OCRs. The proportion of the total PIP in each credible set is attributed to OCRs of each of the five cell lineages or to none. Each horizontal bar corresponds to a credible set, which is labelled in parentheses by the nearest gene to the SNP with the highest PIP; the length of bars of different colors shows the proportion of PIPs assigned to each lineage. Because not all SNPs in the credible sets overlapped with an OCR, some were not assigned to a cell lineage (gray bars). B Cellular context of childhood-onset asthma credible sets. C Adult-onset asthma and childhood-onset asthma candidate CRE ePIP distributions. D Distribution of the number of cell lineages underlying candidate CREs. E Adult-onset asthma and childhood-onset asthma ePIP distributions of candidate CREs (from panels C and D) that overlapped with bronchial epithelial cells MPRA⁺ and MPRA⁻ sequences. The p-values were computed using Wilcoxon rank-sum test