Fig. 7

The disease-associated viral signatures. a Scatter plot of median relative abundances of vOTUs in all investigated disease and control individuals. Gray points represent vOTUs not differentially abundant between two groups, and red and green points represent differentially abundant vOTUs. b Distribution of taxonomic annotation and host assignment of the disease-enriched and control-enriched vOTUs. The vOTUs are grouped at the family level, and the prokaryotic host taxa are also shown at the family level. The number of vOTUs that had more than one predicted host is labeled by red color. c Occurrence rate of most frequent AMGs in all disease-associated vOTUs. The functional categories of AMGs are shown by colored squares. Statistical test was performed using Fisher’s exact test: *, q < 0.05; **, q < 0.01; ***, q < 0.001