Fig. 3

Inter-tumor transcriptional variability is mainly driven by factors other than etiology or location. a Top 7000 genes were averaged across cancer cells in each sample and then clustered. Black broken rectangles demarcate 3 clusters. Cluster 2 is mostly composed of NF2 mutant tumors. b Volcano plots comparing differentially expressed genes between clusters. See Table S2 for the full list of differentially expressed genes. P-values were calculated using a two-sided t-test and corrected for multiple comparisons using FDR. Volcano plots that were similarly obtained by comparing samples in different locations or with different etiologies did now show any significantly differentiated genes after correction for multiple comparisons