Fig. 1
From: A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Multiomic data overview and differential expression analysis of proteins in PTSD. A A schematic overview of the study design and analysis with multiple -omics datasets employed in this study. Dashed lines indicate integration of data-inferred associations in disease. B Distribution of gene and protein expression (all transcripts; gray), protein-coding transcripts (black) and peptides (red). C Volcano plots showing DEPs in DLPFC (top) and sgPFC (bottom) of PTSD brains. Red (P < 0.05 and log fold change > 0) indicates upregulated proteins, and blue (P < 0.05 and log fold change < − 0.18) indicates downregulated proteins. D Top significantly enriched biological pathways in DLPFC and sgPFC for PTSD and MDD differentially expressed proteins