Fig. 5
From: A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
miRNA-regulated disease-associated protein modules. A Correlations between miRNAs with PTSD-associated protein module PTSD-PM-skyblue. Colors in heatmap indicate the correlation levels between miRNAs and proteins. miRNA-protein pairs with P-value < 0.05 are plotted. B Disease-specific protein abundances (log10 Intensity) of hsa-mir-589 targets (CACNA2D1, NEGR1, OPCML, CNTN1), and hsa-mir-6786 targets (ATP6V0A1, LY6H) in module PTSD-PM-skyblue. C Comparison of transcriptional and protein differential expression in PTSD module PTSD-PM-skyblue and grouped linear regression by proteins association with miRNAs. Red, proteins without miRNA association; blue, proteins with miRNA association. D Key driver analysis (KDA) plot of PTSD protein module PTSD-PM-skyblue (top) and MDD protein module MDD-PM-grey60 (bottom). Pink circles indicate key drivers. Colors of individual slices refer to putative miRNA regulation of the protein. E Top: enrichment of GWAS risk genes from TWAS analysis in the proteomic modules of PTSD (top) and MDD (bottom), including Alzheimer’s disease (ALZ), autism spectrum disorder (ASD), bipolar disorder (BIP), major depressive disorder (MDD), post-traumatic stress disorder (PTSD) and schizophrenia (SCZ). Bolded proteins are DEPs (P-value < 0.05) in DLPFC. Colors of bars correspond to their module names. miRNA name abbreviations: MIR103A1, hsa-mir-103a1; MIR218 -1, hsa-mir-218–1; MIR379, hsa-mir- 379; MIR589, has-mir-589; MIR6786, hsa-mir-6786. PM- indicates protein module