Skip to main content

Articles

Page 1 of 40

  1. Three-dimensional (3D) chromatin architecture undergoes dynamic reorganization during mammalian gametogenesis and early embryogenesis. While mouse studies have shown species-specific patterns as well as mechan...

    Authors: Changliang Hou, Geng G. Tian, Shuanggang Hu, Beili Chen, Xiaoyong Li, Bo Xu, Yuedi Cao, Wei Le, Rong Hu, Hao Chen, Yan Zhang, Qian Fang, Man Zhang, Zhaoxia Wang, Zhiguo Zhang, Jinfu Zhang…
    Citation: Genome Medicine 2025 17:57
    Content type: Research Published on:

  2. The human cornea is a transparent and uniquely ordered optical-biological system. Precise coordination of its cellular mechanisms is essential to maintain its transparency and functionality. However, the spati...

    Authors: Dan Jiang, Ke Li, Yining Sun, Zicheng Zhang, Shuang Xie, Xintong Yu, Ruoqi Wang, Ying Feng, Qinxiang Zheng, Yajing Wen, Peter S. Reinach, Yuanyuan Du, Meng Zhou and Wei Chen
    Citation: Genome Medicine 2025 17:56
    Content type: Research Published on:

  3. Mendelian randomization (MR) leverages trait associated genetic variants as instrumental variables (IVs) to determine causal relationships in epidemiology. However, genetic IVs for complex traits are typically...

    Authors: Genevieve M. Leyden, Maria K. Sobczyk, Tom G. Richardson and Tom R. Gaunt
    Citation: Genome Medicine 2025 17:54
    Content type: Research Published on:

  4. Precision oncology has facilitated a transition from a one-size-fits-all to a precise individualized approach. This Comment discusses the broader challenges in the implementation of personalized treatments to ...

    Authors: Elena Fountzilas, Apostolia-Maria Tsimberidou and Razelle Kurzrock
    Citation: Genome Medicine 2025 17:53
    Content type: Comment Published on:

  5. Lysosomal storage disorders (LSDs) have a relatively high incidence among rare diseases and can lead to severe consequences if not treated promptly. However, many countries and regions have not included these ...

    Authors: Xin Wang, Yun Sun, Xian-Wei Guan, Yan-Yun Wang, Dong-Yang Hong, Zhi-Lei Zhang, Ya-Hong Li, Pei-Ying Yang, Tao jiang and Zheng-feng Xu
    Citation: Genome Medicine 2025 17:52
    Content type: Research Published on:

  6. Salmonella enterica subspecies enterica serovar Typhi (abbreviated as ‘Typhi’) is the bacterial agent of typhoid fever. Effective antimicrobial therapy reduces complications and mortality; however, antimicrobial ...

    Authors: Zoe A. Dyson, Louise Cerdeira, Vandana Sharma, Megan E. Carey and Kathryn E. Holt
    Citation: Genome Medicine 2025 17:51
    Content type: Software Published on:

  7. The microbiome of adolescents is poorly understood, as are factors influencing its composition. We aimed to describe the healthy adolescent microbiome and identify early-life and concurrent predictors of its c...

    Authors: Hannah E. Laue, Amy D. Willis, Fang Wang, Melinda C. MacDougall, Yingying Xu, Margaret R. Karagas, Juliette C. Madan, Abby F. Fleisch, Bruce P. Lanphear, Kim M. Cecil, Kimberly Yolton, Aimin Chen, Jessie P. Buckley and Joseph M. Braun
    Citation: Genome Medicine 2025 17:50
    Content type: Research Published on:

  8. Genetic predisposition is particularly common in children with the kidney cancer, Wilms tumor. In 10% of these children, this manifests as a family history of Wilms tumor or bilateral disease. The frequency an...

    Authors: Jenny Wegert, Silke Appenzeller, Taryn D. Treger, Heike Streitenberger, Barbara Ziegler, Sabrina Bausenwein, Christian Vokuhl, Conor Parks, Eva Jüttner, Susanne Gramlich, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Jochen Hubertus, Dietrich von Schweinitz, Birgit Fröhlich…
    Citation: Genome Medicine 2025 17:49
    Content type: Research Published on:

  9. Transcriptional activation of otherwise repressed retrotransposable elements (RTEs) is a hallmark of cancer, shaping tumour progression and immunogenicity by multifaceted, yet incompletely understood, mechanisms.

    Authors: Jane Loong, Rachael Thompson, Callum Hall, Laura Doglio, Judith Pape, Tobias Plowman and George Kassiotis
    Citation: Genome Medicine 2025 17:48
    Content type: Research Published on:

  10. Effective molecular diagnosis of congenital diseases hinges on comprehensive genomic analysis, traditionally reliant on various methodologies specific to each variant type—whole exome or genome sequencing for ...

    Authors: Maria Gridina, Timofey Lagunov, Polina Belokopytova, Nikita Torgunakov, Miroslav Nuriddinov, Artem Nurislamov, Lyudmila P. Nazarenko, Anna A. Kashevarova, Maria E. Lopatkina, Stanislav Vasilyev, Andrey Zuev, Elena O. Belyaeva, Olga A. Salyukova, Aleksandr D. Cheremnykh, Natalia N. Sukhanova, Marina E. Minzhenkova…
    Citation: Genome Medicine 2025 17:47
    Content type: Research Published on:

  11. Antimicrobial resistant (AMR) pathogens represent urgent threats to human health, and their surveillance is of paramount importance. Metagenomic next-generation sequencing (mNGS) has revolutionized such effort...

    Authors: Dan Lu, Katrina L. Kalantar, Abigail L. Glascock, Victoria T. Chu, Estella S. Guerrero, Nina Bernick, Xochitl Butcher, Kirsty Ewing, Elizabeth Fahsbender, Olivia Holmes, Erin Hoops, Ann E. Jones, Ryan Lim, Suzette McCanny, Lucia Reynoso, Karyna Rosario…
    Citation: Genome Medicine 2025 17:46
    Content type: Software Published on:

  12. The convergence of resistance and hypervirulence in Klebsiella pneumoniae represents a significant public health threat, driven by the horizontal transfer of plasmids. Understanding factors affecting plasmid tran...

    Authors: Da-Wei Wei, Yuqin Song, Yi Li, Gang Zhang, Qi Chen, Linhuan Wu, Jiangqing Huang, Xueru Tian, Chao Wang and Jie Feng
    Citation: Genome Medicine 2025 17:45
    Content type: Research Published on:

  13. Deep insights into the metabolic remodelling effects on the immune microenvironment of oesophageal squamous cell carcinoma (ESCC) are crucial for advancing precision immunotherapies and targeted therapies. Thi...

    Authors: Yingzhen Gao, Siyu He, Xiaoyan Meng, Kun Zheng, Heyang Cui, Yikun Cheng, Xinyuan Shen, Yuanfang Zhai, Binbin Zou, Fang Wang, Hongyi Li, Pengzhou Kong, Yanqiang Wang, Xuefei Feng, Bin Yang, Ruifang Sun…
    Citation: Genome Medicine 2025 17:44
    Content type: Research Published on:

  14. Post-traumatic stress disorder (PTSD) is a common and disabling psychiatric disorder. PTSD involves multiple brain regions and is often comorbid with other psychiatric disorders, such as major depressive disor...

    Authors: Jiawei Wang, Yujing Liu, Hongyu Li, Tuan P. Nguyen, John Lee Soto-Vargas, Rashaun Wilson, Weiwei Wang, TuKiet T. Lam, Chi Zhang, Chen Lin, David A. Lewis, Jill Glausier, Paul E. Holtzheimer, Matthew J. Friedman, Kenneth R. Williams, Marina R. Picciotto…
    Citation: Genome Medicine 2025 17:43
    Content type: Research Published on:

  15. Members of the Klebsiella pneumoniae species complex (KpSC) are opportunistic pathogens that cause severe and difficult-to-treat infections. KpSC are common in non-human niches, but the clinical relevance of thes...

    Authors: Marit A. K. Hetland, Mia A. Winkler, Håkon P. Kaspersen, Fredrik Håkonsholm, Ragna-Johanne Bakksjø, Eva Bernhoff, Jose F. Delgado-Blas, Sylvain Brisse, Annapaula Correia, Aasmund Fostervold, Margaret M. C. Lam, Bjørn-Tore Lunestad, Nachiket P. Marathe, Niclas Raffelsberger, Ørjan Samuelsen, Marianne Sunde…
    Citation: Genome Medicine 2025 17:42
    Content type: Research Published on:

  16. Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the pr...

    Authors: Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu and Dong-Dong Wu
    Citation: Genome Medicine 2025 17:41
    Content type: Research Published on:

  17. Both promoters and untranslated regions (UTRs) have critical regulatory roles, yet variants in these regions are largely excluded from clinical genetic testing due to difficulty in interpreting pathogenicity. ...

    Authors: Alexandra C. Martin-Geary, Alexander J.M. Blakes, Ruebena Dawes, Scott D. Findlay, Jenny Lord, Shan Dong, Susan Walker, Jonathan Talbot-Martin, Nechama Wieder, Elston N. D’Souza, Maria Fernandes, Sarah Hilton, Nayana Lahiri, Christopher Campbell, Sarah Jenkinson, Christian G.E.L. DeGoede…
    Citation: Genome Medicine 2025 17:40
    Content type: Research Published on:

  18. DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between ti...

    Authors: Alexander Neumann, Sara Sammallahti, Marta Cosin-Tomas, Sarah E. Reese, Matthew Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrusaityte, Syed H. Arshad, Marian J. Bakermans-Kranenburg, Lawrence Beilin, Carrie Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, Celeste Eng…
    Citation: Genome Medicine 2025 17:39
    Content type: Research Published on:

  19. Variants in genes encoding multiple subunits of the RNA Polymerase III complex which synthesizes rRNAs, tRNAs, and other small RNAs were previously associated with neurological disorders, such as syndromic hyp...

    Authors: Francesca Mattioli, Rún Friðriksdóttir, Anne Hebert, Sissy Bassani, Nazia Ibrahim, Shagufta Naz, Jacqueline Chrast, Clara Pailler-Pradeau, Ásmundur Oddsson, Patrick Sulem, Gisli H. Halldorsson, Páll Melsted, Daníel F. Guðbjartsson, Flavia Palombo, Tommaso Pippucci, Nayereh Nouri…
    Citation: Genome Medicine 2025 17:38
    Content type: Research Published on:

  20. Schwannomas are nerve sheath tumors arising at cranial and peripheral nerves, either sporadically or in patients with a schwannomatosis-predisposition syndrome. There is limited understanding of the transcript...

    Authors: L. Nicolas Gonzalez Castro, Avishai Gavish, Lillian Bussema, Christopher W. Mount, Cyril Neftel, Masashi Nomura, E. Antonio Chiocca, Wenya Linda Bi, Omar Arnaout, Fred G. Barker II, Justin M. Brown, Justin T. Jordan, Tracy T. Batchelor, Anat Stemmer-Rachamimov, Scott R. Plotkin, Itay Tirosh…
    Citation: Genome Medicine 2025 17:37
    Content type: Research Published on:

  21. Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA). However, the causal variants, regulatory elements, and effector gen...

    Authors: Xiaoyuan Zhong, Robert Mitchell, Christine Billstrand, Emma E. Thompson, Noboru J. Sakabe, Ivy Aneas, Isabella M. Salamone, Jing Gu, Anne I. Sperling, Nathan Schoettler, Marcelo A. Nóbrega, Xin He and Carole Ober
    Citation: Genome Medicine 2025 17:35
    Content type: Research Published on:

  22. Klebsiella pneumoniae is an opportunistic pathogen and a leading cause of healthcare-associated infections in hospitals, which are frequently antimicrobial resistant (AMR). Exacerbating the public health threat p...

    Authors: Margaret M. C. Lam, Stephen M. Salisbury, Logan P. Treat, Ryan R. Wick, Louise M. Judd, Kelly L. Wyres, Sylvain Brisse, Kimberly A. Walker, Virginia L. Miller and Kathryn E. Holt
    Citation: Genome Medicine 2025 17:36
    Content type: Research Published on:

  24. Unraveling the spatial configuration of the tumor microenvironment (TME) is crucial for elucidating tumor-immune interactions based on immuno-oncology. We present STopover, a novel approach utilizing spatially...

    Authors: Sungwoo Bae, Hyekyoung Lee, Kwon Joong Na, Dong Soo Lee, Hongyoon Choi and Young Tae Kim
    Citation: Genome Medicine 2025 17:33
    Content type: Method Published on:

  25. A critical area of recent cancer research is the emergence of transition states between normal and cancer that exhibit increased cell plasticity which underlies tumor cell heterogeneity. Pancreatic ductal aden...

    Authors: Emily K.W. Lo, Adrian Idrizi, Rakel Tryggvadottir, Weiqiang Zhou, Wenpin Hou, Hongkai Ji, Patrick Cahan and Andrew P. Feinberg
    Citation: Genome Medicine 2025 17:32
    Content type: Research Published on:

  26. The WHO recently released a second edition of the mutation catalog for predicting drug resistance in Mycobacterium tuberculosis (MTB). This study evaluated its effectiveness compared to existing whole-genome sequ...

    Authors: Yiwang Chen, Xuecong Zhang, Jialei Liang, Qi Jiang, Mijiti Peierdun, Peng Xu, Howard E. Takiff and Qian Gao
    Citation: Genome Medicine 2025 17:31
    Content type: Research Published on:

  27. The gut viral community has been increasingly recognized for its role in human physiology and health; however, our understanding of its genetic makeup, functional potential, and disease associations remains in...

    Authors: Qiulong Yan, Liansha Huang, Shenghui Li, Yue Zhang, Ruochun Guo, Pan Zhang, Zhixin Lei, Qingbo Lv, Fang Chen, Zhiming Li, Jinxin Meng, Jing Li, Guangyang Wang, Changming Chen, Hayan Ullah, Lin Cheng…
    Citation: Genome Medicine 2025 17:30
    Content type: Research Published on:

  28. Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp motifs. TR va...

    Authors: Laurel Hiatt, Ben Weisburd, Egor Dolzhenko, Vincent Rubinetti, Akshay K. Avvaru, Grace E. VanNoy, Nehir Edibe Kurtas, Heidi L. Rehm, Aaron R. Quinlan and Harriet Dashnow
    Citation: Genome Medicine 2025 17:29
    Content type: Database Published on:

  29. Bacterial vaginosis (BV) affects 20–50% of reproductive-age female patients annually, arising when opportunistic pathogens outcompete healthy vaginal flora. Many patients fail to resolve symptoms with a course...

    Authors: Katherine A. Innamorati, Joshua P. Earl, Shirley C. Barrera, Rachel L. Ehrlich, Josephine Aiyeku, Ari Gordon, Evan Powell, Adam C. Retchless, Azad Ahmed, Bhaswati Sen, Sergey Balashov, Joshua Chang Mell, Sharon L. Hillier and Garth D. Ehrlich
    Citation: Genome Medicine 2025 17:28
    Content type: Research Published on:

  30. Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection...

    Authors: Marios K. Georgakis, Rainer Malik, Omar El Bounkari, Natalie R. Hasbani, Jiang Li, Jennifer E. Huffman, Gabrielle Shakt, Reinier W. P. Tack, Tamara N. Kimball, Yaw Asare, Alanna C. Morrison, Noah L. Tsao, Renae Judy, Braxton D. Mitchell, Huichun Xu, May E. Montasser…
    Citation: Genome Medicine 2025 17:27
    Content type: Research Published on:

  31. The complex 2 Mb survival motor neuron (SMN) locus on chromosome 5q13, including the spinal muscular atrophy (SMA)-causing gene SMN1 and modifier SMN2, remains incompletely resolved due to numerous segmental dupl...

    Authors: M. M. Zwartkruis, M. G. Elferink, D. Gommers, I. Signoria, L. Blasco-Pérez, M. Costa-Roger, J. van der Sel, I. J. Renkens, J. W. Green, J. V. Kortooms, C. Vermeulen, R. Straver, H. W. M. van Deutekom, J. H. Veldink, F. Asselman, E. F. Tizzano…
    Citation: Genome Medicine 2025 17:26
    Content type: Research Published on:

  33. Survival of patients with metastatic castration-resistant prostate cancer (mCRPC) depends on the site of metastatic dissemination.

    Authors: Daniel J. Vis, Sander A. L. Palit, Marie Corradi, Edwin Cuppen, Niven Mehra, Martijn P. Lolkema, Lodewyk F. A. Wessels, Michiel S. van der Heijden, Wilbert Zwart and Andries M. Bergman
    Citation: Genome Medicine 2025 17:24
    Content type: Research Published on:

  34. A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGSheight) could identify children ...

    Authors: John P. Shelley, Mingjian Shi, Josh F. Peterson, Sara L. Van Driest, Jill H. Simmons and Jonathan D. Mosley
    Citation: Genome Medicine 2025 17:23
    Content type: Research Published on:

  35. Acute sinusitis (AS) is a frequent cause of antibiotic prescriptions in children. Distinguishing bacterial AS from common viral upper respiratory infections (URIs) is crucial to prevent unnecessary antibiotic ...

    Authors: Andrew C. Doxey, Nooran Abu Mazen, Max Homm, Vivian Chu, Manjot Hunjan, Briallen Lobb, Sojin Lee, Marcia Kurs-Lasky, John V. Williams, William MacDonald, Monika Johnson, Jeremy A. Hirota and Nader Shaikh
    Citation: Genome Medicine 2025 17:22
    Content type: Research Published on:

  37. Alzheimer’s disease (AD) is a complex neurodegenerative disorder with substantial genetic influence. While genome-wide association studies (GWAS) have identified numerous risk loci for late-onset AD (LOAD), th...

    Authors: Ricardo A. Vialle, Katia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, Jose M. Farfel, Lisa L. Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki and David A. Bennett
    Citation: Genome Medicine 2025 17:20
    Content type: Research Published on:

  38. Non-tuberculous mycobacteria (NTM) are a diverse group of environmental bacteria that are increasingly associated with human infections and difficult to treat. Plasmids, which might carry resistance and virule...

    Authors: Margo Diricks, Florian P. Maurer, Viola Dreyer, Ivan Barilar, Christian Utpatel, Matthias Merker, Nils Wetzstein and Stefan Niemann
    Citation: Genome Medicine 2025 17:19
    Content type: Research Published on:

  39. Here we present STModule, a Bayesian method developed to identify tissue modules from spatially resolved transcriptomics that reveal spatial components and essential characteristics of tissues. STModule uncove...

    Authors: Ran Wang, Yan Qian, Xiaojing Guo, Fangda Song, Zhiqiang Xiong, Shirong Cai, Xiuwu Bian, Man Hon Wong, Qin Cao, Lixin Cheng, Gang Lu and Kwong Sak Leung
    Citation: Genome Medicine 2025 17:18
    Content type: Methodology Published on:

  40. We recently reported non-coding variants in a cis-regulatory element of the beta-cell disallowed gene hexokinase 1 (HK1) as a novel cause of congenital hyperinsulinism. These variants lead to a loss of repression...

    Authors: Jasmin J. Bennett, Cécile Saint-Martin, Bianca Neumann, Jonna M. E. Männistö, Jayne A. L. Houghton, Susann Empting, Matthew B. Johnson, Thomas W. Laver, Jonathan M. Locke, Benjamin Spurrier, Matthew N. Wakeling, Indraneel Banerjee, Antonia Dastamani, Hüseyin Demirbilek, John Mitchell, Markus Stange…
    Citation: Genome Medicine 2025 17:17
    Content type: Research Published on:

  41. Spatial transcriptomics (ST) enables the study of gene expression in spatial context, but many ST technologies face challenges due to limited resolution, leading to cell mixtures at each spot. We present LETSm...

    Authors: Yangen Zhan, Yongbing Zhang, Zheqi Hu, Yifeng Wang, Zirui Zhu, Sijing Du, Xiangming Yan and Xiu Li
    Citation: Genome Medicine 2025 17:16
    Content type: Methodology Published on:

  42. Profiling circulating cell-free DNA (cfDNA) has become a fundamental practice in cancer medicine, but the effectiveness of cfDNA at elucidating tumor-derived molecular features has not been systematically comp...

    Authors: Nobuyuki Takahashi, Lorinc Pongor, Shivam P. Agrawal, Mariya Shtumpf, Ankita Gurjar, Vinodh N. Rajapakse, Ahmad Shafiei, Christopher W. Schultz, Sehyun Kim, Diana Roame, Paula Carter, Rasa Vilimas, Samantha Nichols, Parth Desai, William Douglas Figg Sr., Mohammad Bagheri…
    Citation: Genome Medicine 2025 17:15
    Content type: Research Published on:

  43. Helicobacter pylori (H. pylori) infection is a significant risk factor for gastric cancer (GC) development. A growing body of evidence suggests a causal link between infection with H. pylori and increased DNA bre...

    Authors: Hadas Sibony-Benyamini, Rose Jbara, Tania Shubash Napso, Layan Abu-Rahmoun, Daniel Vizenblit, Michal Easton-Mor, Shira Perez, Alexander Brandis, Tamar Leshem, Avi Peretz and Yaakov Maman
    Citation: Genome Medicine 2025 17:14
    Content type: Research Published on:

  44. Authors: Jianping Jiang, Astrid V Cienfuegos-Gallet, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth and Liang Chen
    Citation: Genome Medicine 2025 17:13
    Content type: Correction Published on:

    The original article was published in Genome Medicine 2025 17:9

  45. Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenici...

    Authors: Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk and Peter van Hasselt
    Citation: Genome Medicine 2025 17:12
    Content type: Research Published on:

  46. Ineffective medication is a major healthcare problem causing significant patient suffering and economic costs. This issue stems from the complex nature of diseases, which involve altered interactions among tho...

    Authors: Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik and Mikael Benson
    Citation: Genome Medicine 2025 17:11
    Content type: Review Published on:

  47. Exercise rehabilitation therapy has garnered widespread recognition for its beneficial effects on the restoration of locomotor function in individuals with spinal cord injury (SCI). Notably, resistance exercis...

    Authors: Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng and Lin Cheng
    Citation: Genome Medicine 2025 17:10
    Content type: Research Published on:

  48. Klebsiella pneumoniae is one of the most prevalent pathogens responsible for multiple infections in healthcare settings and the community. K. pneumoniae CG147, primarily including ST147 (the founder ST), ST273, ...

    Authors: Jianping Jiang, Astrid V. Cienfuegos-Gallet, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth and Liang Chen
    Citation: Genome Medicine 2025 17:9
    Content type: Research Published on:

    The Correction to this article has been published in Genome Medicine 2025 17:13

  49. Mixed infection with multiple strains of the same pathogen in a single host can present clinical and analytical challenges. Whole genome sequence (WGS) data can identify signals of multiple strains in samples,...

    Authors: Benjamin Sobkowiak, Patrick Cudahy, Melanie H. Chitwood, Taane G. Clark, Caroline Colijn, Louis Grandjean, Katharine S. Walter, Valeriu Crudu and Ted Cohen
    Citation: Genome Medicine 2025 17:8
    Content type: Research Published on:

  50. Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agno...

    Authors: Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo and Masanori Aikawa
    Citation: Genome Medicine 2025 17:7
    Content type: Research Published on:
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 10.4
    5-year Journal Impact Factor: 12.6
    Source Normalized Impact per Paper (SNIP): 2.375
    SCImago Journal Rank (SJR): 4.975

    Speed 2024
    Submission to first editorial decision (median days): 8
    Submission to acceptance (median days): 224

    Usage 2024
    Downloads: 2,724,546
    Altmetric mentions: 2,349

  • Peer Review Taxonomy

    This journal is participating in a pilot of NISO/STM's Working Group on Peer Review Taxonomy, to identify and standardize definitions and terminology in peer review practices in order to make the peer review process for articles and journals more transparent. Further information on the pilot is available here. 

    The following summary describes the peer review process for this journal:

    • Identity transparency: Single anonymized
    • Reviewer interacts with: Editor
    • Review information published: None

    We welcome your feedback on this Peer Review Taxonomy Pilot. Please can you take the time to complete this short survey.

Genome Medicine

ISSN: 1756-994X

Contact us